You may pass some options to the compiler:
var less = require('less');
less.render('.class { width: (1 + 1) }',
    {
      paths: ['.', './lib'],  // Specify search paths for @import directives
      filename: 'style.less', // Specify a filename, for better error messages
      compress: true          // Minify CSS output
    },
    function (e, output) {
       console.log(output.css);
    });
See Usage for more information.
